JAK/STAT inhibitor therapy partially rescues the lipodystrophic autoimmune phenotype in Clec16a KO mice

CLEC16A is implicated in multiple autoimmune diseases. We generated an inducible whole-body knockout (KO), Clec16a(ΔUBC) mice to address the role of CLEC16A loss of function. KO mice exhibited loss of adipose tissue and severe weight loss in response to defective autophagic flux and exaggerated endo...

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Detalles Bibliográficos
Autores principales: Pandey, Rahul, Bakay, Marina, Strenkowski, Bryan P., Hain, Heather S., Hakonarson, Hakon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8016875/
https://www.ncbi.nlm.nih.gov/pubmed/33795715
http://dx.doi.org/10.1038/s41598-021-86493-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8016875/
https://www.ncbi.nlm.nih.gov/pubmed/33795715
http://dx.doi.org/10.1038/s41598-021-86493-8

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