Loss of microglial SIRPα promotes synaptic pruning in preclinical models of neurodegeneration

Microglia play a key role in regulating synaptic remodeling in the central nervous system. Activation of classical complement pathway promotes microglia-mediated synaptic pruning during development and disease. CD47 protects synapses from excessive pruning during development, implicating microglial...

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Detalles Bibliográficos
Autores principales: Ding, Xin, Wang, Jin, Huang, Miaoxin, Chen, Zhangpeng, Liu, Jing, Zhang, Qipeng, Zhang, Chenyu, Xiang, Yang, Zen, Ke, Li, Liang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8016980/
https://www.ncbi.nlm.nih.gov/pubmed/33795678
http://dx.doi.org/10.1038/s41467-021-22301-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8016980/
https://www.ncbi.nlm.nih.gov/pubmed/33795678
http://dx.doi.org/10.1038/s41467-021-22301-1

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