Linking the YTH domain to cancer: the importance of YTH family proteins in epigenetics

N6-methyladenosine (m6A), the most prevalent and reversible modification of mRNA in mammalian cells, has recently been extensively studied in epigenetic regulation. YTH family proteins, whose YTH domain can recognize and bind m6A-containing RNA, are the main “readers” of m6A modification. YTH family...

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Autores principales: Shi, Rongkai, Ying, Shilong, Li, Yadan, Zhu, Liyuan, Wang, Xian, Jin, Hongchuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8016981/
https://www.ncbi.nlm.nih.gov/pubmed/33795663
http://dx.doi.org/10.1038/s41419-021-03625-8
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author Shi, Rongkai
Ying, Shilong
Li, Yadan
Zhu, Liyuan
Wang, Xian
Jin, Hongchuan
author_facet Shi, Rongkai
Ying, Shilong
Li, Yadan
Zhu, Liyuan
Wang, Xian
Jin, Hongchuan
author_sort Shi, Rongkai
collection PubMed
description N6-methyladenosine (m6A), the most prevalent and reversible modification of mRNA in mammalian cells, has recently been extensively studied in epigenetic regulation. YTH family proteins, whose YTH domain can recognize and bind m6A-containing RNA, are the main “readers” of m6A modification. YTH family proteins perform different functions to determine the metabolic fate of m6A-modified RNA. The crystal structure of the YTH domain has been completely resolved, highlighting the important roles of several conserved residues of the YTH domain in the specific recognition of m6A-modified RNAs. Upstream and downstream targets have been successively revealed in different cancer types and the role of YTH family proteins has been emphasized in m6A research. This review describes the regulation of RNAs by YTH family proteins, the structural features of the YTH domain, and the connections of YTH family proteins with human cancers.
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spelling pubmed-80169812021-04-16 Linking the YTH domain to cancer: the importance of YTH family proteins in epigenetics Shi, Rongkai Ying, Shilong Li, Yadan Zhu, Liyuan Wang, Xian Jin, Hongchuan Cell Death Dis Review Article N6-methyladenosine (m6A), the most prevalent and reversible modification of mRNA in mammalian cells, has recently been extensively studied in epigenetic regulation. YTH family proteins, whose YTH domain can recognize and bind m6A-containing RNA, are the main “readers” of m6A modification. YTH family proteins perform different functions to determine the metabolic fate of m6A-modified RNA. The crystal structure of the YTH domain has been completely resolved, highlighting the important roles of several conserved residues of the YTH domain in the specific recognition of m6A-modified RNAs. Upstream and downstream targets have been successively revealed in different cancer types and the role of YTH family proteins has been emphasized in m6A research. This review describes the regulation of RNAs by YTH family proteins, the structural features of the YTH domain, and the connections of YTH family proteins with human cancers. Nature Publishing Group UK 2021-04-01 /pmc/articles/PMC8016981/ /pubmed/33795663 http://dx.doi.org/10.1038/s41419-021-03625-8 Text en © The Author(s) 2021 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Review Article
Shi, Rongkai
Ying, Shilong
Li, Yadan
Zhu, Liyuan
Wang, Xian
Jin, Hongchuan
Linking the YTH domain to cancer: the importance of YTH family proteins in epigenetics
title Linking the YTH domain to cancer: the importance of YTH family proteins in epigenetics
title_full Linking the YTH domain to cancer: the importance of YTH family proteins in epigenetics
title_fullStr Linking the YTH domain to cancer: the importance of YTH family proteins in epigenetics
title_full_unstemmed Linking the YTH domain to cancer: the importance of YTH family proteins in epigenetics
title_short Linking the YTH domain to cancer: the importance of YTH family proteins in epigenetics
title_sort linking the yth domain to cancer: the importance of yth family proteins in epigenetics
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8016981/
https://www.ncbi.nlm.nih.gov/pubmed/33795663
http://dx.doi.org/10.1038/s41419-021-03625-8
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