The use of HEPES-buffer in the production of gallium-68 radiopharmaceuticals – time to reconsider strict pharmacopoeial limits?

HEPES (4-(2-hydroxyethyl) piperazine-1-ethanesulfonic acid) is a buffer that is used in the radiolabelling of gallium-68 compounds. The beneficial effects of HEPES on molar activity in bioconjugates have been well described. Current strict regulations on the HEPES content in radiopharmaceuticals lim...

Descripción completa

Detalles Bibliográficos
Autores principales: le Roux, Jannie, Kleynhans, Janke, Rubow, Sietske
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2021
Materias:
Letter to the Editor
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8017018/
https://www.ncbi.nlm.nih.gov/pubmed/33796967
http://dx.doi.org/10.1186/s41181-021-00129-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8017018/
https://www.ncbi.nlm.nih.gov/pubmed/33796967
http://dx.doi.org/10.1186/s41181-021-00129-w

Ejemplares similares