Stepwise Reversion of Multiply Mutated Recombinant Antitrypsin Reveals a Selective Inhibitor of Coagulation Factor XIa as Active as the M358R Variant

Alpha-1 antitrypsin (AAT, also known as alpha-1 proteinase inhibitor or SERPINA1) is the most abundant member of the serpin superfamily found in human plasma. The naturally occurring variant AAT M358R, altered at the P1 position of the critical reactive center loop (RCL), is re-directed away from in...

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Detalles Bibliográficos
Autores principales: Hamada, Mostafa, Bhakta, Varsha, Andres, Sara N., Sheffield, William P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Cardiovascular Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8017132/
https://www.ncbi.nlm.nih.gov/pubmed/33816577
http://dx.doi.org/10.3389/fcvm.2021.647405

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8017132/
https://www.ncbi.nlm.nih.gov/pubmed/33816577
http://dx.doi.org/10.3389/fcvm.2021.647405

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