Human PD-1(hi)CD8(+) T Cells Are a Cellular Source of IL-21 in Rheumatoid Arthritis

BACKGROUND: Rheumatoid arthritis (RA) is a prototypical autoantibody-driven autoimmune disease in which T-B interactions play a critical role. Recent comprehensive analysis suggests that PD-1(+)CD8(+) T cells as well as two distinct IL-21-producing PD-1(+)CD4(+) T cell subsets, follicular helper T (...

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Detalles Bibliográficos
Autores principales: Higashioka, Kazuhiko, Yoshimura, Motoki, Sakuragi, Takahide, Ayano, Masahiro, Kimoto, Yasutaka, Mitoma, Hiroki, Ono, Nobuyuki, Arinobu, Yojiro, Kikukawa, Makoto, Yamada, Hisakata, Horiuchi, Takahiko, Akashi, Koichi, Niiro, Hiroaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8017303/
https://www.ncbi.nlm.nih.gov/pubmed/33815416
http://dx.doi.org/10.3389/fimmu.2021.654623

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8017303/
https://www.ncbi.nlm.nih.gov/pubmed/33815416
http://dx.doi.org/10.3389/fimmu.2021.654623

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