NLRC5 regulates expression of MHC-I and provides a target for anti-tumor immunity in transmissible cancers

PURPOSE: Downregulation of MHC class I (MHC-I) is a common immune evasion strategy of many cancers. Similarly, two allogeneic clonal transmissible cancers have killed thousands of wild Tasmanian devils (Sarcophilus harrisii) and also modulate MHC-I expression to evade anti-cancer and allograft respo...

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Detalles Bibliográficos
Autores principales: Ong, Chrissie E. B., Patchett, Amanda L., Darby, Jocelyn M., Chen, Jinying, Liu, Guei-Sheung, Lyons, A. Bruce, Woods, Gregory M., Flies, Andrew S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
Original Article – Cancer Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8017436/
https://www.ncbi.nlm.nih.gov/pubmed/33797607
http://dx.doi.org/10.1007/s00432-021-03601-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8017436/
https://www.ncbi.nlm.nih.gov/pubmed/33797607
http://dx.doi.org/10.1007/s00432-021-03601-x

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