Kidney intercalated cells and the transcription factor FOXi1 drive cystogenesis in tuberous sclerosis complex

Tuberous sclerosis complex (TSC) is caused by mutations in either TSC1 or TSC2 genes and affects multiple organs, including kidney, lung, and brain. In the kidney, TSC presents with the enlargement of benign tumors (angiomyolipomata) and cysts, which eventually leads to kidney failure. The factors p...

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Detalles Bibliográficos
Autores principales: Barone, Sharon, Zahedi, Kamyar, Brooks, Marybeth, Henske, Elizabeth P., Yang, Yirong, Zhang, Erik, Bissler, John J., Yu, Jane J., Soleimani, Manoocher
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2021
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8017711/
https://www.ncbi.nlm.nih.gov/pubmed/33536341
http://dx.doi.org/10.1073/pnas.2020190118

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8017711/
https://www.ncbi.nlm.nih.gov/pubmed/33536341
http://dx.doi.org/10.1073/pnas.2020190118

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