Autophagy is required for proper cysteine homeostasis in pancreatic cancer through regulation of SLC7A11

Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest forms of cancer and is highly refractory to current therapies. We had previously shown that PDAC can utilize its high levels of basal autophagy to support its metabolism and maintain tumor growth. Consistent with the importance of autop...

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Detalles Bibliográficos
Autores principales: Mukhopadhyay, Subhadip, Biancur, Douglas E., Parker, Seth J., Yamamoto, Keisuke, Banh, Robert S., Paulo, Joao A., Mancias, Joseph D., Kimmelman, Alec C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2021
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8017731/
https://www.ncbi.nlm.nih.gov/pubmed/33531365
http://dx.doi.org/10.1073/pnas.2021475118

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8017731/
https://www.ncbi.nlm.nih.gov/pubmed/33531365
http://dx.doi.org/10.1073/pnas.2021475118

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