A novel age-informed approach for genetic association analysis in Alzheimer’s disease

BACKGROUND: Many Alzheimer’s disease (AD) genetic association studies disregard age or incorrectly account for it, hampering variant discovery. METHODS: Using simulated data, we compared the statistical power of several models: logistic regression on AD diagnosis adjusted and not adjusted for age; l...

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Detalles Bibliográficos
Autores principales: Le Guen, Yann, Belloy, Michael E., Napolioni, Valerio, Eger, Sarah J., Kennedy, Gabriel, Tao, Ran, He, Zihuai, Greicius, Michael D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8017764/
https://www.ncbi.nlm.nih.gov/pubmed/33794991
http://dx.doi.org/10.1186/s13195-021-00808-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8017764/
https://www.ncbi.nlm.nih.gov/pubmed/33794991
http://dx.doi.org/10.1186/s13195-021-00808-5

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