Combinatorial efficacy of entospletinib and chemotherapy in patient-derived xenograft models of infant acute lymphoblastic leukemia

Survival of infants with KMT2A-rearranged acute lymphoblastic leukemia (ALL) remains dismal despite intensive chemotherapy. We observed constitutive phosphorylation of spleen tyrosine kinase (SYK) and associated signaling proteins in infant ALL patient-derived xenograft (PDX) model specimens and hyp...

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Detalles Bibliográficos
Autores principales: Loftus, Joseph P., Yahiaoui, Anella, Brown, Patrick A, Niswander, Lisa M., Bagashev, Asen, Wang, Min, Shauf, Allyson, Tannheimer, Stacey, Tasian, Sarah K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Fondazione Ferrata Storti 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8018117/
https://www.ncbi.nlm.nih.gov/pubmed/32414848
http://dx.doi.org/10.3324/haematol.2019.241729

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8018117/
https://www.ncbi.nlm.nih.gov/pubmed/32414848
http://dx.doi.org/10.3324/haematol.2019.241729

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