Cargando…

Overexpressed Tumor Suppressor Exosomal miR-15a-5p in Cancer Cells Inhibits PD1 Expression in CD8+T Cells and Suppresses the Hepatocellular Carcinoma Progression

BACKGROUND: Hepatocellular carcinoma (HCC) is the most common primary liver tumor, and the main reason is the unclear pathogenesis of HCC, which leads to a high fatality rate of HCC. Therefore, it is of great clinical significance to explore the molecular mechanism of HCC and find a targeted therape...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Hong-Yu, Liang, Hong-Xia, Wu, Shu-Huan, Jiang, He-Qing, Wang, Qin, Yu, Zu-Jiang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8018596/ https://www.ncbi.nlm.nih.gov/pubmed/33816255 http://dx.doi.org/10.3389/fonc.2021.622263

Ejemplares similares

CD205(+) polymorphonuclear myeloid‐derived suppressor cells suppress antitumor immunity by overexpressing GLUT3
por: Fu, Chenghao, et al.
Publicado: (2021)

Serum-derived exosomes promote CD8+ T cells to overexpress PD-1, affecting the prognosis of hypopharyngeal carcinoma
por: Gao, Qian, et al.
Publicado: (2021)

Tumor-derived exosomes induce CD8(+) T cell suppressors
por: Maybruck, Brian T., et al.
Publicado: (2017)

GOLM1 exacerbates CD8(+) T cell suppression in hepatocellular carcinoma by promoting exosomal PD-L1 transport into tumor-associated macrophages
por: Chen, Jinhong, et al.
Publicado: (2021)

The Mechanism of miR-155/miR-15b Axis Contributed to Apoptosis of CD34+ Cells by Upregulation of PD-L1 in Myelodysplastic Syndromes
por: Cao, MeiWan, et al.
Publicado: (2023)

Exosome-derived circCCAR1 promotes CD8 + T-cell dysfunction and anti-PD1 resistance in hepatocellular carcinoma
por: Hu, Zongqiang, et al.
Publicado: (2023)

Exosomes derived from mir-214-3p overexpressing mesenchymal stem cells promote myocardial repair
por: Zhu, Wenwu, et al.
Publicado: (2023)

Human CD8(+)CD28(−) T Suppressor Cells Expanded by IL-15 In Vitro Suppress in an Allospecific and Programmed Cell Death Protein 1-Dependent Manner
por: Feng, Fu, et al.
Publicado: (2018)

Overexpression of CD155 is associated with PD-1 and PD-L1 expression on immune cells, rather than tumor cells in the breast cancer microenvironment
por: Wang, Rui-Bin, et al.
Publicado: (2020)

Construction of Exosomes that Overexpress CD47 and Evaluation of Their Immune Escape
por: Ben, Xin-Yu, et al.
Publicado: (2022)

Adriamycin‐loaded exosome with anti‐CD20 aptamers selectively suppresses human CD20+ melanoma stem cells
por: Chen, Hairong, et al.
Publicado: (2022)

Reactive oxygen species reprogram macrophages to suppress antitumor immune response through the exosomal miR-155-5p/PD-L1 pathway
por: Li, Xiang, et al.
Publicado: (2022)

miR-589-5p inhibits MAP3K8 and suppresses CD90(+) cancer stem cells in hepatocellular carcinoma
por: Zhang, Xi, et al.
Publicado: (2016)

Circular RNA circFADS2 is overexpressed in sepsis and suppresses LPS-induced lung cell apoptosis by inhibiting the maturation of miR-15a-5p
por: Hong, Xiaoyang, et al.
Publicado: (2021)

Exosomes with overexpressed miR 147a suppress angiogenesis and infammatory injury in an experimental model of atopic dermatitis
por: Shi, Chenlong, et al.
Publicado: (2023)

The suppression of cervical cancer ferroptosis by macrophages: The attenuation of ALOX15 in cancer cells by macrophages-derived exosomes
por: Luo, Yanlin, et al.
Publicado: (2023)

Nasopharyngeal cancer cell‐derived exosomal PD‐L1 inhibits CD8+ T‐cell activity and promotes immune escape
por: Yang, Jie, et al.
Publicado: (2022)

circEPS15 Overexpression in Hepatocellular Carcinoma Modulates Tumor Invasion and Migration
por: Jiang, Bin, et al.
Publicado: (2022)

Exosomes Derived from miR-143-Overexpressing MSCs Inhibit Cell Migration and Invasion in Human Prostate Cancer by Downregulating TFF3
por: Che, Yuanyuan, et al.
Publicado: (2019)

miR-211 suppresses hepatocellular carcinoma by downregulating SATB2
por: Jiang, Guixing, et al.
Publicado: (2015)

Breast Cancer Metastasis Suppressor 1 Regulates Hepatocellular Carcinoma Cell Apoptosis via Suppressing Osteopontin Expression
por: Wu, Yanhua, et al.
Publicado: (2012)

miR-15a and miR-15b modulate natural killer and CD8(+)T-cell activation and anti-tumor immune response by targeting PD-L1 in neuroblastoma
por: Pathania, Anup S., et al.
Publicado: (2022)

p65/miR‐23a/CCL22 axis regulated regulatory T cells recruitment in hepatitis B virus positive hepatocellular carcinoma
por: Li, Zhi‐Qin, et al.
Publicado: (2019)

Exosomes from miR-23 Overexpressing Stromal Cells Suppress M1 Macrophage and Inhibit Calcium Oxalate Deposition in Hyperoxaluria Rat Model
por: Yifan, Zhang, et al.
Publicado: (2023)

Overexpression of miR-15b Promotes Resistance to Sunitinib in Renal Cell Carcinoma
por: Lu, Lu, et al.
Publicado: (2019)

MicroRNA-125b Functions as a Tumor Suppressor in Hepatocellular Carcinoma Cells
por: Jia, Hong-Yan, et al.
Publicado: (2012)

Melanoma-Derived Exosomes Induce PD-1 Overexpression and Tumor Progression via Mesenchymal Stem Cell Oncogenic Reprogramming
por: Gyukity-Sebestyén, Edina, et al.
Publicado: (2019)

The identification and functional analysis of CD8+PD-1+CD161+ T cells in hepatocellular carcinoma
por: Li, Zhixuan, et al.
Publicado: (2020)

PD-1 is a haploinsufficient suppressor of T cell lymphomagenesis
por: Wartewig, Tim, et al.
Publicado: (2017)

Cancer-Associated Fibroblasts-Derived Exosomes Suppress Immune Cell Function in Breast Cancer via the miR-92/PD-L1 Pathway
por: Dou, Dongwei, et al.
Publicado: (2020)

Clinical significance of PD-1/PD-Ls gene amplification and overexpression in patients with hepatocellular carcinoma
por: Ma, Li-Jie, et al.
Publicado: (2018)

CD93 overexpresses in liver hepatocellular carcinoma and represents a potential immunotherapy target
por: Jiang, Qianwei, et al.
Publicado: (2023)

Prostate cancer cells synergistically defend against CD8 (+) T cells by secreting exosomal PD‐L1
por: Li, Dameng, et al.
Publicado: (2023)

PIK3C2A mRNA functions as a miR-124 sponge to facilitate CD151 expression and enhance malignancy of hepatocellular carcinoma cells
por: Liu, Tao, et al.
Publicado: (2016)

Enhanced Production of Exosome-Associated AAV by Overexpression of the Tetraspanin CD9
por: Schiller, Lara Timantra, et al.
Publicado: (2018)

Ubiquitinated Proteins in Exosomes Secreted by Myeloid-Derived Suppressor Cells
por: Burke, Meghan C., et al.
Publicado: (2014)

Exosomes from Adipose-Derived Stem Cells (ADSCs) Overexpressing miR-21 Promote Vascularization of Endothelial Cells
por: An, Yang, et al.
Publicado: (2019)

RGFP966 Suppresses Tumor Growth and Migration Through Inhibition of EGFR Expression in Hepatocellular Carcinoma Cells in vitro
por: Yu, Xinying, et al.
Publicado: (2020)

Early Activation of Myeloid-Derived Suppressor Cells Participate in Sepsis-Induced Immune Suppression via PD-L1/PD-1 Axis
por: Ruan, Wei-Shuyi, et al.
Publicado: (2020)

Retraction Notice to: Exosomes Derived from miR-143-Overexpressing MSCs Inhibit Cell Migration and Invasion in Human Prostate Cancer by Downregulating TFF3
por: Che, Yuanyuan, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_i24f715ttt8ts9ee70qfooueb9