Evaluation of AXIN1 and AXIN2 as targets of tankyrase inhibition in hepatocellular carcinoma cell lines

AXIN1 mutations are observed in 8–10% of hepatocellular carcinomas (HCCs) and originally were considered to support tumor growth by aberrantly enhancing β-catenin signaling. This view has however been challenged by reports showing neither a clear nuclear β-catenin accumulation nor clearly enhanced e...

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Detalles Bibliográficos
Autores principales: Wang, Wenhui, Liu, Pengyu, Lavrijsen, Marla, Li, Shan, Zhang, Ruyi, Li, Shanshan, van de Geer, Wesley S., van de Werken, Harmen J. G., Peppelenbosch, Maikel P., Smits, Ron
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8018973/
https://www.ncbi.nlm.nih.gov/pubmed/33811251
http://dx.doi.org/10.1038/s41598-021-87091-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8018973/
https://www.ncbi.nlm.nih.gov/pubmed/33811251
http://dx.doi.org/10.1038/s41598-021-87091-4

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