Knockout of c‐Cbl slows EGFR endocytic trafficking and enhances EGFR signaling despite incompletely blocking receptor ubiquitylation

Epidermal growth factor receptor (EGFR) activity is necessary and sufficient for corneal epithelial homeostasis. However, the addition of exogenous Epidermal Growth Factor (EGF) does not reliably restore the corneal epithelium when wounded. This is likely due to high levels of endogenous EGF in tear...

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Detalles Bibliográficos
Autores principales: Crotchett, Brandon L. M., Ceresa, Brian P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8019067/
https://www.ncbi.nlm.nih.gov/pubmed/33811466
http://dx.doi.org/10.1002/prp2.756

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8019067/
https://www.ncbi.nlm.nih.gov/pubmed/33811466
http://dx.doi.org/10.1002/prp2.756

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