Antivirulence DsbA inhibitors attenuate Salmonella enterica serovar Typhimurium fitness without detectable resistance

Inhibition of the DiSulfide Bond (DSB) oxidative protein folding machinery, a major facilitator of virulence in Gram‐negative bacteria, represents a promising antivirulence strategy. We previously developed small molecule inhibitors of DsbA from Escherichia coli K‐12 (EcDsbA) and showed that they at...

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Detalles Bibliográficos
Autores principales: Dhouib, Rabeb, Vagenas, Dimitrios, Hong, Yaoqin, Verderosa, Anthony D., Martin, Jennifer L, Heras, Begoña, Totsika, Makrina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8019255/
https://www.ncbi.nlm.nih.gov/pubmed/33842848
http://dx.doi.org/10.1096/fba.2020-00100

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8019255/
https://www.ncbi.nlm.nih.gov/pubmed/33842848
http://dx.doi.org/10.1096/fba.2020-00100

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