Iminostilbene, a novel small-molecule modulator of PKM2, suppresses macrophage inflammation in myocardial ischemia–reperfusion injury

INTRODUCTION: Inflammation is a key factor in myocardial ischemia/reperfusion (MI/R) injury. Targeting leucocyte-mediated inflammation is an important strategy for MI/R therapy. Iminostilbene (ISB), a simple dibenzoazepine small molecule compound, has a strong anti-neurodegenerative effect. However,...

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Detalles Bibliográficos
Autores principales: Lu, Shan, Tian, Yu, Luo, Yun, Xu, Xudong, Ge, Wenxiu, Sun, Guibo, Sun, Xiaobo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Basic and Biological Science
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8020153/
https://www.ncbi.nlm.nih.gov/pubmed/33842007
http://dx.doi.org/10.1016/j.jare.2020.09.001

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8020153/
https://www.ncbi.nlm.nih.gov/pubmed/33842007
http://dx.doi.org/10.1016/j.jare.2020.09.001

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