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Iminostilbene, a novel small-molecule modulator of PKM2, suppresses macrophage inflammation in myocardial ischemia–reperfusion injury

INTRODUCTION: Inflammation is a key factor in myocardial ischemia/reperfusion (MI/R) injury. Targeting leucocyte-mediated inflammation is an important strategy for MI/R therapy. Iminostilbene (ISB), a simple dibenzoazepine small molecule compound, has a strong anti-neurodegenerative effect. However,...

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Detalles Bibliográficos
Autores principales:	Lu, Shan, Tian, Yu, Luo, Yun, Xu, Xudong, Ge, Wenxiu, Sun, Guibo, Sun, Xiaobo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2020
Materias:	Basic and Biological Science
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8020153/ https://www.ncbi.nlm.nih.gov/pubmed/33842007 http://dx.doi.org/10.1016/j.jare.2020.09.001

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