Gintonin facilitates brain delivery of donepezil, a therapeutic drug for Alzheimer disease, through lysophosphatidic acid 1/3 and vascular endothelial growth factor receptors

BACKGROUND: Gintonin is a ginseng-derived exogenous G-protein–coupled lysophosphatidic acid (LPA) receptor ligand, which exhibits in vitro and in vivo functions against Alzheimer disease (AD) through lysophosphatidic acid 1/3 receptors. A recent study demonstrated that systemic treatment with ginton...

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Detalles Bibliográficos
Autores principales: Choi, Sun-Hye, Lee, Na-Eun, Cho, Hee-Jung, Lee, Ra Mi, Rhim, Hyewhon, Kim, Hyoung-Chun, Han, Mun, Lee, Eun-Hee, Park, Juyoung, Nah, Seung-Yeol
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8020287/
https://www.ncbi.nlm.nih.gov/pubmed/33841007
http://dx.doi.org/10.1016/j.jgr.2019.12.002

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8020287/
https://www.ncbi.nlm.nih.gov/pubmed/33841007
http://dx.doi.org/10.1016/j.jgr.2019.12.002

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