20(S)-ginsenoside Rh2 induces caspase-dependent promyelocytic leukemia-retinoic acid receptor A degradation in NB4 cells via Akt/Bax/caspase9 and TNF-α/caspase8 signaling cascades

BACKGROUND: Acute promyelocytic leukemia (APL) is a hematopoietic malignancy driven by promyelocytic leukemia–retinoic acid receptor A (PML-RARA) fusion gene. The therapeutic drugs currently used to treat APL have adverse effects. 20(S)-ginsenoside Rh2 (GRh2) is an anticancer medicine with high effe...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhu, Sirui, Liu, Xiaoli, Xue, Mei, Li, Yu, Cai, Danhong, Wang, Shijun, Zhang, Liang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8020289/
https://www.ncbi.nlm.nih.gov/pubmed/33841010
http://dx.doi.org/10.1016/j.jgr.2020.05.001

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8020289/
https://www.ncbi.nlm.nih.gov/pubmed/33841010
http://dx.doi.org/10.1016/j.jgr.2020.05.001

Ejemplares similares