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20(S)-ginsenoside Rh2 induces caspase-dependent promyelocytic leukemia-retinoic acid receptor A degradation in NB4 cells via Akt/Bax/caspase9 and TNF-α/caspase8 signaling cascades

BACKGROUND: Acute promyelocytic leukemia (APL) is a hematopoietic malignancy driven by promyelocytic leukemia–retinoic acid receptor A (PML-RARA) fusion gene. The therapeutic drugs currently used to treat APL have adverse effects. 20(S)-ginsenoside Rh2 (GRh2) is an anticancer medicine with high effe...

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Detalles Bibliográficos
Autores principales:	Zhu, Sirui, Liu, Xiaoli, Xue, Mei, Li, Yu, Cai, Danhong, Wang, Shijun, Zhang, Liang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8020289/ https://www.ncbi.nlm.nih.gov/pubmed/33841010 http://dx.doi.org/10.1016/j.jgr.2020.05.001

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