Predicting HCC Response to Multikinase Inhibitors With In Vivo Cirrhotic Mouse Model for Personalized Therapy

BACKGROUND & AIMS: Hepatocellular carcinoma (HCC) arises in a cirrhotic, pro-angiogenic microenvironment. Inhibiting angiogenesis is a key mode of action of multikinase inhibitors and current non-cirrhotic models are unable to predict treatment response. We present a novel mouse cirrhotic model...

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Detalles Bibliográficos
Autores principales: Huang, Daniel Q., Muthiah, Mark D., Zhou, Lei, Jumat, Halisah, Tan, Wan Xin, Lee, Guan Huei, Lim, Seng Gee, Kow, Alfred, Bonney, Glenn, Shridhar, Iyer, Lim, Yi Ting, Wee, Aileen, Pang, Yin Huei, Soon, Gwyneth, Chow, Pierce, Dan, Yock Young
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8020437/
https://www.ncbi.nlm.nih.gov/pubmed/33340714
http://dx.doi.org/10.1016/j.jcmgh.2020.12.009

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8020437/
https://www.ncbi.nlm.nih.gov/pubmed/33340714
http://dx.doi.org/10.1016/j.jcmgh.2020.12.009

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