Selective cysteine-to-selenocysteine changes in a [NiFe]-hydrogenase confirm a special position for catalysis and oxygen tolerance

In [NiFe]-hydrogenases, the active-site Ni is coordinated by four cysteine-S ligands (Cys; C), two of which are bridging to the Fe(CO)(CN)(2) fragment. Substitution of a single Cys residue by selenocysteine (Sec; U) occurs occasionally in nature. Using a recent method for site-specific Sec incorpora...

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Detalles Bibliográficos
Autores principales: Evans, Rhiannon M., Krahn, Natalie, Murphy, Bonnie J., Lee, Harrison, Armstrong, Fraser A., Söll, Dieter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2021
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8020662/
https://www.ncbi.nlm.nih.gov/pubmed/33753519
http://dx.doi.org/10.1073/pnas.2100921118

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8020662/
https://www.ncbi.nlm.nih.gov/pubmed/33753519
http://dx.doi.org/10.1073/pnas.2100921118

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