Cancer-specific loss of TERT activation sensitizes glioblastoma to DNA damage

Most glioblastomas (GBMs) achieve cellular immortality by acquiring a mutation in the telomerase reverse transcriptase (TERT) promoter. TERT promoter mutations create a binding site for a GA binding protein (GABP) transcription factor complex, whose assembly at the promoter is associated with TERT r...

Descripción completa

Detalles Bibliográficos
Autores principales: Amen, Alexandra M., Fellmann, Christof, Soczek, Katarzyna M., Ren, Shawn M., Lew, Rachel J., Knott, Gavin J., Park, Jesslyn E., McKinney, Andrew M., Mancini, Andrew, Doudna, Jennifer A., Costello, Joseph F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2021
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8020668/
https://www.ncbi.nlm.nih.gov/pubmed/33758097
http://dx.doi.org/10.1073/pnas.2008772118

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8020668/
https://www.ncbi.nlm.nih.gov/pubmed/33758097
http://dx.doi.org/10.1073/pnas.2008772118

Ejemplares similares