Cargando…

Cancer-specific loss of TERT activation sensitizes glioblastoma to DNA damage

Most glioblastomas (GBMs) achieve cellular immortality by acquiring a mutation in the telomerase reverse transcriptase (TERT) promoter. TERT promoter mutations create a binding site for a GA binding protein (GABP) transcription factor complex, whose assembly at the promoter is associated with TERT r...

Descripción completa

Detalles Bibliográficos
Autores principales:	Amen, Alexandra M., Fellmann, Christof, Soczek, Katarzyna M., Ren, Shawn M., Lew, Rachel J., Knott, Gavin J., Park, Jesslyn E., McKinney, Andrew M., Mancini, Andrew, Doudna, Jennifer A., Costello, Joseph F.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2021
Materias:	Biological Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8020668/ https://www.ncbi.nlm.nih.gov/pubmed/33758097 http://dx.doi.org/10.1073/pnas.2008772118

Ejemplares similares

CRISPR-Cas9 bends and twists DNA to read its sequence
por: Cofsky, Joshua C., et al.
Publicado: (2022)

Conserved features of TERT promoter duplications reveal an activation mechanism that mimics hotspot mutations in cancer
por: Barger, Carter J., et al.
Publicado: (2022)

GABP couples oncogene signaling to telomere regulation in TERT promoter mutant cancer
por: McKinney, Andrew M., et al.
Publicado: (2022)

Potent CRISPR-Cas9 inhibitors from Staphylococcus genomes
por: Watters, Kyle E., et al.
Publicado: (2020)

Structural basis for AcrVA4 inhibition of specific CRISPR-Cas12a
por: Knott, Gavin J, et al.
Publicado: (2019)

Genome expansion by a CRISPR trimmer-integrase
por: Wang, Joy Y., et al.
Publicado: (2023)

Hyperpolarized δ-[1- (13)C]gluconolactone imaging visualizes response to TERT or GABPB1 targeting therapy for glioblastoma
por: Minami, Noriaki, et al.
Publicado: (2023)

IL-1 TERT PROMOTER C228T MUTATION IN NEURAL PROGENITORS CONFERS GROWTH ADVANTAGE FOLLOWING TELOMERE SHORTENING IN VIVO
por: Furnari, Frank, et al.
Publicado: (2022)

The genomic landscape of TERT promoter wildtype-IDH wildtype glioblastoma
por: Diplas, Bill H., et al.
Publicado: (2018)

TERT Promoter Alterations in Glioblastoma: A Systematic Review
por: Olympios, Nathalie, et al.
Publicado: (2021)

Endogenous spacing enables co-processing of microRNAs and efficient combinatorial RNAi
por: Amen, Alexandra M., et al.
Publicado: (2022)

Crystal structure of an RNA/DNA strand exchange junction
por: Cofsky, Joshua C., et al.
Publicado: (2022)

TERT promoter mutations and polymorphisms as prognostic factors in primary glioblastoma
por: Mosrati, Mohamed Ali, et al.
Publicado: (2015)

Site-Specific Bioconjugation through Enzyme-Catalyzed Tyrosine–Cysteine Bond Formation
por: Lobba, Marco J., et al.
Publicado: (2020)

Intraspecific functional diversity of common species enhances community stability
por: Wood, Connor M., et al.
Publicado: (2017)

Rapid endotheliitis and vascular damage characterize SARS‐CoV‐2 infection in a human lung‐on‐chip model
por: Thacker, Vivek V, et al.
Publicado: (2021)

Nrf2-driven TERT regulates pentose phosphate pathway in glioblastoma
por: Ahmad, F, et al.
Publicado: (2016)

New somatic TERT promoter variants enhance the Telomerase activity in Glioblastoma
por: Pierini, Tiziana, et al.
Publicado: (2020)

Prognostic Impact of the Combination of MGMT Methylation and TERT Promoter Mutation in Glioblastoma
por: Tunthanathip, Thara, et al.
Publicado: (2021)

Molecular landscape of IDH ‐wild type, pTERT ‐wild type adult glioblastomas
por: Liu, Emma Munan, et al.
Publicado: (2022)

Comprehensive deletion landscape of CRISPR-Cas9 identifies minimal RNA-guided DNA-binding modules
por: Shams, Arik, et al.
Publicado: (2021)

CryoEM structures of open dimers of gyrase A in complex with DNA illuminate mechanism of strand passage
por: Soczek, Katarzyna M, et al.
Publicado: (2018)

4-tert-Butylpyridinium triiodide–4-tert-butylpyridine (1/1)
por: He, Hongshan, et al.
Publicado: (2011)

Rapid assessment of SARS-CoV-2–evolved variants using virus-like particles
por: Syed, Abdullah M., et al.
Publicado: (2021)

TERT promoter mutations and monoallelic activation of TERT in cancer
por: Huang, F W, et al.
Publicado: (2015)

Profiling of engineering hotspots identifies an allosteric CRISPR-Cas9 switch
por: Oakes, Benjamin L, et al.
Publicado: (2016)

Prognostic role of ALK-1 and h-TERT expression in glioblastoma multiforme: correlation with ALK gene alterations
por: Elsers, Dalia, et al.
Publicado: (2021)

The Role of the DNA Damage Response throughout the Papillomavirus Life Cycle
por: McKinney, Caleb C., et al.
Publicado: (2015)

Glioblastoma lacking necrosis or vascular proliferations: Different clinical presentation but similar outcome, regardless of histology or isolated TERT promoter mutation
por: Wijnenga, Maarten M J, et al.
Publicado: (2023)

Allele‐specific proximal promoter hypomethylation of the telomerase reverse transcriptase gene (TERT) associates with TERT expression in multiple cancers
por: Rowland, Teisha J., et al.
Publicado: (2020)

Prognostic impact of CDKN2A/B deletion, TERT mutation, and EGFR amplification on histological and molecular IDH-wildtype glioblastoma
por: Ma, Sirui, et al.
Publicado: (2020)

TERT mutations-associated alterations in clinical characteristics, immune environment and therapy response in glioblastomas
por: Tang, Feng, et al.
Publicado: (2023)

TERT, a promoter of CNS malignancies
por: Patel, Bhuvic, et al.
Publicado: (2020)

Cell-free DNA and circulating TERT promoter mutation for disease monitoring in newly-diagnosed glioblastoma
por: Fontanilles, Maxime, et al.
Publicado: (2020)

Telomere Length, TERT, and miRNA Expression
por: Slattery, Martha L., et al.
Publicado: (2016)

Observing Beam Motion Using Infrared Interferometry
por: Byrd, J M, et al.
Publicado: (1999)

tert-Butyldimethylsilanol hemihydrate
por: Barry, Sarah M., et al.
Publicado: (2008)

Reactivation of Tert in the medial prefrontal cortex and hippocampus rescues aggression and depression of Tert(−/−) mice
por: Zhou, Q-G, et al.
Publicado: (2016)

TERT—Regulation and Roles in Cancer Formation
por: Dratwa, Marta, et al.
Publicado: (2020)

Impact of CDKN2A/B, MTAP, and TERT Genetic Alterations on Survival in IDH Wild Type Glioblastomas
por: Hsu, Eric J., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_5rqedcsi4hfk9dj6p18jcknj90