CMT2N-causing aminoacylation domain mutants enable Nrp1 interaction with AlaRS

Through dominant mutations, aminoacyl-tRNA synthetases constitute the largest protein family linked to Charcot-Marie-Tooth disease (CMT). An example is CMT subtype 2N (CMT2N), caused by individual mutations spread out in AlaRS, including three in the aminoacylation domain, thereby suggesting a role...

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Detalles Bibliográficos
Autores principales: Sun, Litao, Wei, Na, Kuhle, Bernhard, Blocquel, David, Novick, Scott, Matuszek, Zaneta, Zhou, Huihao, He, Weiwei, Zhang, Jingjing, Weber, Thomas, Horvath, Rita, Latour, Philippe, Pan, Tao, Schimmel, Paul, Griffin, Patrick R., Yang, Xiang-Lei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2021
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8020758/
https://www.ncbi.nlm.nih.gov/pubmed/33753480
http://dx.doi.org/10.1073/pnas.2012898118

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8020758/
https://www.ncbi.nlm.nih.gov/pubmed/33753480
http://dx.doi.org/10.1073/pnas.2012898118

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