CD4 receptor diversity represents an ancient protection mechanism against primate lentiviruses

Infection with human and simian immunodeficiency viruses (HIV/SIV) requires binding of the viral envelope glycoprotein (Env) to the host protein CD4 on the surface of immune cells. Although invariant in humans, the Env binding domain of the chimpanzee CD4 is highly polymorphic, with nine coding vari...

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Detalles Bibliográficos
Autores principales: Russell, Ronnie M., Bibollet-Ruche, Frederic, Liu, Weimin, Sherrill-Mix, Scott, Li, Yingying, Connell, Jesse, Loy, Dorothy E., Trimboli, Stephanie, Smith, Andrew G., Avitto, Alexa N., Gondim, Marcos V. P., Plenderleith, Lindsey J., Wetzel, Katherine S., Collman, Ronald G., Ayouba, Ahidjo, Esteban, Amandine, Peeters, Martine, Kohler, William J., Miller, Richard A., François-Souquiere, Sandrine, Switzer, William M., Hirsch, Vanessa M., Marx, Preston A., Piel, Alex K., Stewart, Fiona A., Georgiev, Alexander V., Sommer, Volker, Bertolani, Paco, Hart, John A., Hart, Terese B., Shaw, George M., Sharp, Paul M., Hahn, Beatrice H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2021
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8020793/
https://www.ncbi.nlm.nih.gov/pubmed/33771926
http://dx.doi.org/10.1073/pnas.2025914118

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8020793/
https://www.ncbi.nlm.nih.gov/pubmed/33771926
http://dx.doi.org/10.1073/pnas.2025914118

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