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TAR DNA-Binding Protein 43 Is Associated with Rate of Memory, Functional and Global Cognitive Decline in the Decade Prior to Death

BACKGROUND: Transactive response DNA-binding protein of 43 kDa (TDP-43) is associated with memory impairment and overall cognitive decline. It is unclear how TDP-43 contributes to the rate of clinical decline. OBJECTIVE: To determine whether cross-sectional and longitudinal cognitive and functional...

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Detalles Bibliográficos
Autores principales: Buciuc, Marina, Tosakulwong, Nirubol, Machulda, Mary M., Whitwell, Jennifer L., Weigand, Stephen D., Murray, Melissa E., Reichard, R. Ross, Parisi, Joseph E., Dickson, Dennis W., Boeve, Bradley F., Knopman, David S., Petersen, Ronald C., Josephs, Keith A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IOS Press 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8020877/
https://www.ncbi.nlm.nih.gov/pubmed/33579840
http://dx.doi.org/10.3233/JAD-201166