To knot or not to knot: Multiple conformations of the SARS-CoV-2 frameshifting RNA element

The SARS-CoV-2 frameshifting RNA element (FSE) is an excellent target for therapeutic intervention against Covid-19. This small gene element employs a shifting mechanism to pause and backtrack the ribosome during translation between Open Reading Frames 1a and 1b, which code for viral polyproteins. A...

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Detalles Bibliográficos
Autores principales: Schlick, Tamar, Zhu, Qiyao, Dey, Abhishek, Jain, Swati, Yan, Shuting, Laederach, Alain
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8020974/
https://www.ncbi.nlm.nih.gov/pubmed/33821274
http://dx.doi.org/10.1101/2021.03.31.437955

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8020974/
https://www.ncbi.nlm.nih.gov/pubmed/33821274
http://dx.doi.org/10.1101/2021.03.31.437955

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