The pentose phosphate pathway mediates hyperoxia-induced lung vascular dysgenesis and alveolar simplification in neonates

Dysmorphic pulmonary vascular growth and abnormal endothelial cell (EC) proliferation are paradoxically observed in premature infants with bronchopulmonary dysplasia (BPD), despite vascular pruning. The pentose phosphate pathway (PPP), a metabolic pathway parallel to glycolysis, generates NADPH as a...

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Detalles Bibliográficos
Autores principales: Gong, Jiannan, Feng, Zihang, Peterson, Abigail L., Carr, Jennifer F., Lu, Xuexin, Zhao, Haifeng, Ji, Xiangming, Zhao, You-Yang, De Paepe, Monique E., Dennery, Phyllis A., Yao, Hongwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8021105/
https://www.ncbi.nlm.nih.gov/pubmed/33497360
http://dx.doi.org/10.1172/jci.insight.137594

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8021105/
https://www.ncbi.nlm.nih.gov/pubmed/33497360
http://dx.doi.org/10.1172/jci.insight.137594

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