Tet1 Deficiency Leads to Premature Ovarian Failure

Tet enzymes participate in DNA demethylation and play critical roles in stem cell pluripotency and differentiation. DNA methylation alters with age. We find that Tet1 deficiency reduces fertility and leads to accelerated reproductive failure with age. Noticeably, Tet1-deficient mice at young age exh...

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Detalles Bibliográficos
Autores principales: Liu, Linlin, Wang, Huasong, Xu, Guo_Liang, Liu, Lin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8021788/
https://www.ncbi.nlm.nih.gov/pubmed/33834024
http://dx.doi.org/10.3389/fcell.2021.644135

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8021788/
https://www.ncbi.nlm.nih.gov/pubmed/33834024
http://dx.doi.org/10.3389/fcell.2021.644135

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