Seed-mediated RNA interference of androgen signaling and survival networks induces cell death in prostate cancer cells

Resistance to anti-androgen therapy in prostate cancer (PCa) is often driven by genetic and epigenetic aberrations in the androgen receptor (AR) and coregulators that maintain androgen signaling activity. We show that specific small RNAs downregulate expression of multiple essential and androgen rec...

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Detalles Bibliográficos
Autores principales: Corbin, Joshua M., Georgescu, Constantin, Wren, Jonathan D., Xu, Chao, Asch, Adam S., Ruiz-Echevarría, Maria J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8022159/
https://www.ncbi.nlm.nih.gov/pubmed/33850637
http://dx.doi.org/10.1016/j.omtn.2021.03.002

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8022159/
https://www.ncbi.nlm.nih.gov/pubmed/33850637
http://dx.doi.org/10.1016/j.omtn.2021.03.002

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