The paradox of autophagy in Tuberous Sclerosis Complex

Tuberous sclerosis complex (TSC) is an autosomal dominant genetic disorder caused by germline mutations in TSC1 or TSC2 genes, which leads to the hyperactivation of the mTORC1 pathway, an important negative regulator of autophagy. This leads to the development of hamartomas in multiple organs. The v...

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Detalles Bibliográficos
Autores principales: Reis, Larissa Brussa, Filippi-Chiela, Eduardo C., Ashton-Prolla, Patricia, Visioli, Fernanda, Rosset, Clévia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira de Genética 2021
Materias:
Human and Medical Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8022228/
https://www.ncbi.nlm.nih.gov/pubmed/33821877
http://dx.doi.org/10.1590/1678-4685-GMB-2020-0014

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8022228/
https://www.ncbi.nlm.nih.gov/pubmed/33821877
http://dx.doi.org/10.1590/1678-4685-GMB-2020-0014

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