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Structural basis for conformational equilibrium of the catalytic spliceosome
The ATPase Prp16 governs equilibrium between the branching (B(∗)/C) and exon ligation (C(∗)/P) conformations of the spliceosome. Here, we present the electron cryomicroscopy reconstruction of the Saccharomyces cerevisiae C-complex spliceosome at 2.8 Å resolution and identify a novel C-complex interm...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Cell Press
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8022279/ https://www.ncbi.nlm.nih.gov/pubmed/33705709 http://dx.doi.org/10.1016/j.molcel.2021.02.021 |