Selectivity via Cooperativity: Preferential Stabilization of the p65/14-3-3 Interaction with Semisynthetic Natural Products

[Image: see text] Natural compounds are an important class of potent drug molecules including some retrospectively found to act as stabilizers of protein–protein interactions (PPIs). However, the design of synthetic PPI stabilizers remains an understudied approach. To date, there are limited example...

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Detalles Bibliográficos
Autores principales: Wolter, Madita, de Vink, Pim, Neves, João Filipe, Srdanović, Sonja, Higuchi, Yusuke, Kato, Nobuo, Wilson, Andrew, Landrieu, Isabelle, Brunsveld, Luc, Ottmann, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8022324/
https://www.ncbi.nlm.nih.gov/pubmed/32501683
http://dx.doi.org/10.1021/jacs.0c02151

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8022324/
https://www.ncbi.nlm.nih.gov/pubmed/32501683
http://dx.doi.org/10.1021/jacs.0c02151

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