Structure, function and inhibition of critical protein–protein interactions involving mixed lineage leukemia 1 and its fusion oncoproteins

Mixed lineage leukemia 1 (MLL1, also known as MLL or KMT2A) is an important transcription factor and histone-H3 lysine-4 (H3K4) methyltransferase. It is a master regulator for transcription of important genes (e.g., Hox genes) for embryonic development and hematopoiesis. However, it is largely dispe...

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Detalles Bibliográficos
Autores principales: Li, Xin, Song, Yongcheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8022399/
https://www.ncbi.nlm.nih.gov/pubmed/33823889
http://dx.doi.org/10.1186/s13045-021-01057-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8022399/
https://www.ncbi.nlm.nih.gov/pubmed/33823889
http://dx.doi.org/10.1186/s13045-021-01057-7

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