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GSK3β rephosphorylation rescues ALPL deficiency-induced impairment of odontoblastic differentiation of DPSCs
BACKGROUND: Premature exfoliation of the deciduous teeth is a common manifestation in childhood patients with hypophosphatasia (HPP), which is an autosomal inherited disease caused by ALPL mutations. Dysplasia of the cementum, dentin, and alveolar bone has been proposed to be the main reasons for th...
Autores principales: | Zhang, Liqiang, Zhao, Jiangdong, Dong, Jiayi, Liu, Yuting, Xuan, Kun, Liu, Wenjia |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8022410/ https://www.ncbi.nlm.nih.gov/pubmed/33823913 http://dx.doi.org/10.1186/s13287-021-02235-7 |
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