TREM2/PLCγ2 signalling in immune cells: function, structural insight, and potential therapeutic modulation

The central role of the resident innate immune cells of the brain (microglia) in neurodegeneration has become clear over the past few years largely through genome-wide association studies (GWAS), and has rapidly become an active area of research. However, a mechanistic understanding (gene to functio...

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Autores principales: Magno, Lorenza, Bunney, Tom D., Mead, Emma, Svensson, Fredrik, Bictash, Magda N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8022522/
https://www.ncbi.nlm.nih.gov/pubmed/33823896
http://dx.doi.org/10.1186/s13024-021-00436-5
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author Magno, Lorenza
Bunney, Tom D.
Mead, Emma
Svensson, Fredrik
Bictash, Magda N.
author_facet Magno, Lorenza
Bunney, Tom D.
Mead, Emma
Svensson, Fredrik
Bictash, Magda N.
author_sort Magno, Lorenza
collection PubMed
description The central role of the resident innate immune cells of the brain (microglia) in neurodegeneration has become clear over the past few years largely through genome-wide association studies (GWAS), and has rapidly become an active area of research. However, a mechanistic understanding (gene to function) has lagged behind. That is now beginning to change, as exemplified by a number of recent exciting and important reports that provide insight into the function of two key gene products – TREM2 (Triggering Receptor Expressed On Myeloid Cells 2) and PLCγ2 (Phospholipase C gamma2) – in microglia, and their role in neurodegenerative disorders. In this review we explore and discuss these recent advances and the opportunities that they may provide for the development of new therapies.
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spelling pubmed-80225222021-04-07 TREM2/PLCγ2 signalling in immune cells: function, structural insight, and potential therapeutic modulation Magno, Lorenza Bunney, Tom D. Mead, Emma Svensson, Fredrik Bictash, Magda N. Mol Neurodegener Review The central role of the resident innate immune cells of the brain (microglia) in neurodegeneration has become clear over the past few years largely through genome-wide association studies (GWAS), and has rapidly become an active area of research. However, a mechanistic understanding (gene to function) has lagged behind. That is now beginning to change, as exemplified by a number of recent exciting and important reports that provide insight into the function of two key gene products – TREM2 (Triggering Receptor Expressed On Myeloid Cells 2) and PLCγ2 (Phospholipase C gamma2) – in microglia, and their role in neurodegenerative disorders. In this review we explore and discuss these recent advances and the opportunities that they may provide for the development of new therapies. BioMed Central 2021-04-06 /pmc/articles/PMC8022522/ /pubmed/33823896 http://dx.doi.org/10.1186/s13024-021-00436-5 Text en © The Author(s) 2021 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Magno, Lorenza
Bunney, Tom D.
Mead, Emma
Svensson, Fredrik
Bictash, Magda N.
TREM2/PLCγ2 signalling in immune cells: function, structural insight, and potential therapeutic modulation
title TREM2/PLCγ2 signalling in immune cells: function, structural insight, and potential therapeutic modulation
title_full TREM2/PLCγ2 signalling in immune cells: function, structural insight, and potential therapeutic modulation
title_fullStr TREM2/PLCγ2 signalling in immune cells: function, structural insight, and potential therapeutic modulation
title_full_unstemmed TREM2/PLCγ2 signalling in immune cells: function, structural insight, and potential therapeutic modulation
title_short TREM2/PLCγ2 signalling in immune cells: function, structural insight, and potential therapeutic modulation
title_sort trem2/plcγ2 signalling in immune cells: function, structural insight, and potential therapeutic modulation
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8022522/
https://www.ncbi.nlm.nih.gov/pubmed/33823896
http://dx.doi.org/10.1186/s13024-021-00436-5
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