Cargando…
TREM2/PLCγ2 signalling in immune cells: function, structural insight, and potential therapeutic modulation
The central role of the resident innate immune cells of the brain (microglia) in neurodegeneration has become clear over the past few years largely through genome-wide association studies (GWAS), and has rapidly become an active area of research. However, a mechanistic understanding (gene to functio...
Autores principales: | Magno, Lorenza, Bunney, Tom D., Mead, Emma, Svensson, Fredrik, Bictash, Magda N. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8022522/ https://www.ncbi.nlm.nih.gov/pubmed/33823896 http://dx.doi.org/10.1186/s13024-021-00436-5 |
Ejemplares similares
-
PLCγ2 regulates TREM2 signalling and integrin-mediated adhesion and migration of human iPSC-derived macrophages
por: Obst, Juliane, et al.
Publicado: (2021) -
Dynamic Allostery in PLCγ1 and Its Modulation by a Cancer Mutation Revealed by MD Simulation and NMR
por: Koss, Hans, et al.
Publicado: (2018) -
Structural and Functional Integration of the PLCγ Interaction Domains Critical for Regulatory Mechanisms and Signaling Deregulation
por: Bunney, Tom D., et al.
Publicado: (2012) -
Time-resolved FRET reports FGFR1 dimerization and formation of a complex with its effector PLCγ1
por: Perdios, Louis, et al.
Publicado: (2016) -
Involvement of Src kinases and PLCγ2 in clot retraction
por: Suzuki-Inoue, Katsue, et al.
Publicado: (2007)