Fuzziness and Frustration in the Energy Landscape of Protein Folding, Function, and Assembly

[Image: see text] Are all protein interactions fully optimized? Do suboptimal interactions compromise specificity? What is the functional impact of frustration? Why does evolution not optimize some contacts? Proteins and their complexes are best described as ensembles of states populating an energy...

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Detalles Bibliográficos
Autores principales: Gianni, Stefano, Freiberger, María Inés, Jemth, Per, Ferreiro, Diego U., Wolynes, Peter G., Fuxreiter, Monika
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8023570/
https://www.ncbi.nlm.nih.gov/pubmed/33550810
http://dx.doi.org/10.1021/acs.accounts.0c00813

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8023570/
https://www.ncbi.nlm.nih.gov/pubmed/33550810
http://dx.doi.org/10.1021/acs.accounts.0c00813

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