Cargando…
Insights into the Dynamics of the Human Zinc Transporter ZnT8 by MD Simulations
[Image: see text] ZnT8 is a human zinc(II) transporter expressed at the membrane of secretory granules where it contributes to insulin storage importing zinc ions from the cytosol. In the human population, the two most common ZnT8 variants carry an arginine (R325) or a tryptophan (W325) in position...
Autores principales: | Sala, Davide, Giachetti, Andrea, Rosato, Antonio |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical
Society
2021
|
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8023586/ https://www.ncbi.nlm.nih.gov/pubmed/33508935 http://dx.doi.org/10.1021/acs.jcim.0c01139 |
Ejemplares similares
-
Zinc transporter 8 (ZnT8) autoantibody epitope specificity and affinity examined with recombinant ZnT8 variant proteins in specific ZnT8R and ZnT8W autoantibody-positive type 1 diabetes patients
por: Skärstrand, H, et al.
Publicado: (2015) -
Angiotensin II Requires Zinc and Downregulation of the Zinc Transporters ZnT3 and ZnT10 to Induce Senescence of Vascular Smooth Muscle Cells
por: Patrushev, Nikolay, et al.
Publicado: (2012) -
Genetic association of zinc transporter 8 (ZnT8) autoantibodies in type 1 diabetes cases
por: Howson, J. M. M., et al.
Publicado: (2012) -
Association of Zinc Transporter-8 Autoantibody (ZnT8A) with Type 1 Diabetes Mellitus
por: Bhatty, Afreen, et al.
Publicado: (2020) -
ZnT8 Haploinsufficiency Impacts MIN6 Cell Zinc Content and β-Cell Phenotype via ZIP-ZnT8 Coregulation
por: Lawson, Rebecca, et al.
Publicado: (2019)