Engineering of Ancestors as a Tool to Elucidate Structure, Mechanism, and Specificity of Extant Terpene Cyclase

[Image: see text] Structural information is crucial for understanding catalytic mechanisms and to guide enzyme engineering efforts of biocatalysts, such as terpene cyclases. However, low sequence similarity can impede homology modeling, and inherent protein instability presents challenges for struct...

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Detalles Bibliográficos
Autores principales: Schriever, Karen, Saenz-Mendez, Patricia, Rudraraju, Reshma Srilakshmi, Hendrikse, Natalie M., Hudson, Elton P., Biundo, Antonino, Schnell, Robert, Syrén, Per-Olof
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8023661/
https://www.ncbi.nlm.nih.gov/pubmed/33496585
http://dx.doi.org/10.1021/jacs.0c10214

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8023661/
https://www.ncbi.nlm.nih.gov/pubmed/33496585
http://dx.doi.org/10.1021/jacs.0c10214

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