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Carboxylesterase Activities and Protein Expression in Rabbit and Pig Ocular Tissues

[Image: see text] Hydrolytic reactions constitute an important pathway of drug metabolism and a significant route of prodrug activation. Many ophthalmic drugs and prodrugs contain ester groups that greatly enhance their permeation across several hydrophobic barriers in the eye before the drugs are e...

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Detalles Bibliográficos
Autores principales: Hammid, Anam, Fallon, John K., Lassila, Toni, Salluce, Giulia, Smith, Philip C., Tolonen, Ari, Sauer, Achim, Urtti, Arto, Honkakoski, Paavo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8023712/
https://www.ncbi.nlm.nih.gov/pubmed/33595329
http://dx.doi.org/10.1021/acs.molpharmaceut.0c01154