Time-resolved phosphoproteomics reveals scaffolding and catalysis-responsive patterns of SHP2-dependent signaling

SHP2 is a protein tyrosine phosphatase that normally potentiates intracellular signaling by growth factors, antigen receptors, and some cytokines, yet is frequently mutated in human cancer. Here, we examine the role of SHP2 in the responses of breast cancer cells to EGF by monitoring phosphoproteome...

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Detalles Bibliográficos
Autores principales: Vemulapalli, Vidyasiri, Chylek, Lily A, Erickson, Alison, Pfeiffer, Anamarija, Gabriel, Khal-Hentz, LaRochelle, Jonathan, Subramanian, Kartik, Cao, Ruili, Stegmaier, Kimberley, Mohseni, Morvarid, LaMarche, Matthew J, Acker, Michael G, Sorger, Peter K, Gygi, Steven P, Blacklow, Stephen C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8024022/
https://www.ncbi.nlm.nih.gov/pubmed/33755016
http://dx.doi.org/10.7554/eLife.64251

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8024022/
https://www.ncbi.nlm.nih.gov/pubmed/33755016
http://dx.doi.org/10.7554/eLife.64251

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