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Unmasking coupling between channel gating and ion permeation in the muscle nicotinic receptor

Whether ion channel gating is independent of ion permeation has been an enduring, unresolved question. Here, applying single channel recording to the archetypal muscle nicotinic receptor, we unmask coupling between channel gating and ion permeation by structural perturbation of a conserved intramemb...

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Detalles Bibliográficos
Autores principales: Strikwerda, John R, Sine, Steven M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8024024/
https://www.ncbi.nlm.nih.gov/pubmed/33821794
http://dx.doi.org/10.7554/eLife.66225