Structural basis for dimerization quality control

Most quality control pathways target misfolded proteins to prevent toxic aggregation and neurodegeneration (1). Dimerization quality control (DQC) further improves proteostasis by eliminating complexes of aberrant composition (2), yet how it detects incorrect subunits is still unknown. Here, we prov...

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Detalles Bibliográficos
Autores principales: Mena, Elijah L., Jevtić, Predrag, Greber, Basil J., Gee, Christine L., Lew, Brandon G., Akopian, David, Nogales, Eva, Kuriyan, John, Rape, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8024055/
https://www.ncbi.nlm.nih.gov/pubmed/32814905
http://dx.doi.org/10.1038/s41586-020-2636-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8024055/
https://www.ncbi.nlm.nih.gov/pubmed/32814905
http://dx.doi.org/10.1038/s41586-020-2636-7

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