MLL3 suppresses tumorigenesis through regulating TNS3 enhancer activity

MLL3 is a histone H3K4 methyltransferase that is frequently mutated in cancer, but the underlying molecular mechanisms remain elusive. Here, we found that MLL3 depletion by CRISPR/sgRNA significantly enhanced cell migration, but did not elevate the proliferation rate of cancer cells. Through RNA-Seq...

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Detalles Bibliográficos
Autores principales: Zheng, Jun-Yi, Wang, Chen-Yu, Gao, Chuan, Xiao, Qiong, Huang, Cheng-Wei, Wu, Min, Li, Lian-Yun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8024252/
https://www.ncbi.nlm.nih.gov/pubmed/33824309
http://dx.doi.org/10.1038/s41419-021-03647-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8024252/
https://www.ncbi.nlm.nih.gov/pubmed/33824309
http://dx.doi.org/10.1038/s41419-021-03647-2

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