A slowly cleaved viral signal peptide acts as a protein-integral immune evasion domain

Stress can induce cell surface expression of MHC-like ligands, including MICA, that activate NK cells. Human cytomegalovirus (HCMV) glycoprotein US9 downregulates the activating immune ligand MICA*008 to avoid NK cell activation, but the underlying mechanism remains unclear. Here, we show that the N...

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Detalles Bibliográficos
Autores principales: Seidel, Einat, Dassa, Liat, Kahlon, Shira, Tirosh, Boaz, Halenius, Anne, Seidel Malkinson, Tal, Mandelboim, Ofer
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8024260/
https://www.ncbi.nlm.nih.gov/pubmed/33824318
http://dx.doi.org/10.1038/s41467-021-21983-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8024260/
https://www.ncbi.nlm.nih.gov/pubmed/33824318
http://dx.doi.org/10.1038/s41467-021-21983-x

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