Cargando…

Development of a bispecific immune engager using a recombinant malaria protein

As an immune evasion and survival strategy, the Plasmodium falciparum malaria parasite has evolved a protein named VAR2CSA. This protein mediates sequestration of infected red blood cells in the placenta through the interaction with a unique carbohydrate abundantly and exclusively present in the pla...

Descripción completa

Detalles Bibliográficos
Autores principales:	Nordmaj, Mie A., Roberts, Morgan E., Sachse, Emilie S., Dagil, Robert, Andersen, Anne Poder, Skeltved, Nanna, Grunddal, Kaare V., Erdoğan, Sayit Mahmut, Choudhary, Swati, Gustsavsson, Tobias, Ørum-Madsen, Maj Sofie, Moskalev, Igor, Tian, Weihua, Yang, Zhang, Clausen, Thomas M., Theander, Thor G., Daugaard, Mads, Nielsen, Morten A., Salanti, Ali
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8024270/ https://www.ncbi.nlm.nih.gov/pubmed/33824272 http://dx.doi.org/10.1038/s41419-021-03611-0

Ejemplares similares

Bispecific T cell-engager targeting oncofetal chondroitin sulfate induces complete tumor regression and protective immune memory in mice
por: Skeltved, Nanna, et al.
Publicado: (2023)

Real-time and label free determination of ligand binding-kinetics to primary cancer tissue specimens; a novel tool for the assessment of biomarker targeting
por: Clausen, Thomas Mandel, et al.
Publicado: (2016)

Capture and Detection of Circulating Glioma Cells Using the Recombinant VAR2CSA Malaria Protein
por: Bang-Christensen, Sara R., et al.
Publicado: (2019)

A simple method for detecting oncofetal chondroitin sulfate glycosaminoglycans in bladder cancer urine
por: Clausen, Thomas Mandel, et al.
Publicado: (2020)

Oncofetal Chondroitin Sulfate: A Putative Therapeutic Target in Adult and Pediatric Solid Tumors
por: Khazamipour, Nastaran, et al.
Publicado: (2020)

Placental Sequestration of Plasmodium falciparum Malaria Parasites Is Mediated by the Interaction Between VAR2CSA and Chondroitin Sulfate A on Syndecan-1
por: Ayres Pereira, Marina, et al.
Publicado: (2016)

The VAR2CSA malaria protein efficiently retrieves circulating tumor cells in an EpCAM-independent manner
por: Agerbæk, Mette Ø., et al.
Publicado: (2018)

Author Correction: The VAR2CSA malaria protein efficiently retrieves circulating tumor cells in an EpCAM-independent manner
por: Agerbæk, Mette Ø., et al.
Publicado: (2022)

Cryo-EM reveals the architecture of placental malaria VAR2CSA and provides molecular insight into chondroitin sulfate binding
por: Wang, Kaituo, et al.
Publicado: (2021)

Internalization and trafficking of CSPG-bound recombinant VAR2CSA lectins in cancer cells
por: Wang, Chris Kedong, et al.
Publicado: (2022)

Sub-grouping of Plasmodium falciparum 3D7 var genes based on sequence analysis of coding and non-coding regions
por: Lavstsen, Thomas, et al.
Publicado: (2003)

Detection of VAR2CSA-Captured Colorectal Cancer Cells from Blood Samples by Real-Time Reverse Transcription PCR
por: Bang-Christensen, Sara R., et al.
Publicado: (2021)

Oncofetal Chondroitin Sulfate Is a Highly Expressed Therapeutic Target in Non-Small Cell Lung Cancer
por: Oo, Htoo Zarni, et al.
Publicado: (2021)

Reformation of the chondroitin sulfate glycocalyx enables progression of AR-independent prostate cancer
por: Al-Nakouzi, Nader, et al.
Publicado: (2022)

The Chondroitin Sulfate A-binding Site of the VAR2CSA Protein Involves Multiple N-terminal Domains
por: Dahlbäck, Madeleine, et al.
Publicado: (2011)

Structural Insight into Epitopes in the Pregnancy-Associated Malaria Protein VAR2CSA
por: Andersen, Pernille, et al.
Publicado: (2008)

Changes in var gene mRNA levels during erythrocytic development in two phenotypically distinct Plasmodium falciparum parasites
por: Dahlbäck, Madeleine, et al.
Publicado: (2007)

Utilizing Nanobody Technology to Target Non-Immunodominant Domains of VAR2CSA
por: Ditlev, Sisse B., et al.
Publicado: (2014)

The kinetics of antibody binding to Plasmodium falciparum VAR2CSA PfEMP1 antigen and modelling of PfEMP1 antigen packing on the membrane knobs
por: Joergensen, Lars M, et al.
Publicado: (2010)

Optimization of rVAR2-Based Isolation of Cancer Cells in Blood for Building a Robust Assay for Clinical Detection of Circulating Tumor Cells
por: Sand, Nicolai T., et al.
Publicado: (2020)

A method for visualizing surface-exposed and internal PfEMP1 adhesion antigens in Plasmodium falciparum infected erythrocytes
por: Bengtsson, Dominique, et al.
Publicado: (2008)

Structure function analysis of P. falciparum VAR2CSA
por: Dahlbäck, Madeleine, et al.
Publicado: (2010)

Expression of Plasmodium falciparum erythrocyte membrane protein 1 in experimentally infected humans
por: Lavstsen, Thomas, et al.
Publicado: (2005)

Identification of glycosaminoglycan binding regions in the Plasmodium falciparum encoded placental sequestration ligand, VAR2CSA
por: Resende, Mafalda, et al.
Publicado: (2008)

Several domains from VAR2CSA can induce Plasmodium falciparum adhesion-blocking antibodies
por: Salanti, Ali, et al.
Publicado: (2010)

Bispecific antibodies and their applications
por: Fan, Gaowei, et al.
Publicado: (2015)

The making of bispecific antibodies
por: Brinkmann, Ulrich, et al.
Publicado: (2017)

Bacterial superglue generates a full-length circumsporozoite protein virus-like particle vaccine capable of inducing high and durable antibody responses
por: Janitzek, Christoph M., et al.
Publicado: (2016)

A cVLP-Based Vaccine Displaying Full-Length PCSK9 Elicits a Higher Reduction in Plasma PCSK9 Than Similar Peptide-Based cVLP Vaccines
por: Goksøyr, Louise, et al.
Publicado: (2022)

BEAT(® )the bispecific challenge: a novel and efficient platform for the expression of bispecific IgGs
por: Moretti, Pierre, et al.
Publicado: (2013)

A Novel Virus-Like Particle Based Vaccine Platform Displaying the Placental Malaria Antigen VAR2CSA
por: Thrane, Susan, et al.
Publicado: (2015)

A proof-of-concept study for the design of a VLP-based combinatorial HPV and placental malaria vaccine
por: Janitzek, Christoph M., et al.
Publicado: (2019)

Capsid-like particles decorated with the SARS-CoV-2 receptor-binding domain elicit strong virus neutralization activity
por: Fougeroux, Cyrielle, et al.
Publicado: (2021)

Homogeneous Bispecifics by Disulfide Bridging
por: Hull, Elizabeth A., et al.
Publicado: (2014)

Design and Production of Bispecific Antibodies
por: Wang, Qiong, et al.
Publicado: (2019)

Bispecific Antibodies for Diagnostic Applications
por: Parashar, Archana, et al.
Publicado: (2011)

Bispecific Antibodies and Gene Therapy
por: Nettelbeck, Dirk M.
Publicado: (2011)

Differential Induction of Functional IgG Using the Plasmodium falciparum Placental Malaria Vaccine Candidate VAR2CSA
por: Pinto, Vera V., et al.
Publicado: (2011)

Full-Length Recombinant Plasmodium falciparum VAR2CSA Binds Specifically to CSPG and Induces Potent Parasite Adhesion-Blocking Antibodies
por: Khunrae, Pongsak, et al.
Publicado: (2010)

Tethered-variable C(L) bispecific IgG: an antibody platform for rapid bispecific antibody screening
por: Kim, Hok Seon, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_j87ra4nm99cbgvp9b2jsb08p2t