Dominant role of CDKN2B/p15INK4B of 9p21.3 tumor suppressor hub in inhibition of cell-cycle and glycolysis

Human chromosome 9p21.3 is susceptible to inactivation in cell immortalization and diseases, such as cancer, coronary artery disease and type-2 diabetes. Although this locus encodes three cyclin-dependent kinase (CDK) inhibitors (p15(INK4B), p14(ARF) and p16(INK4A)), our understanding of their funct...

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Detalles Bibliográficos
Autores principales: Xia, Yong, Liu, Yan, Yang, Chao, Simeone, Diane M., Sun, Tung-Tien, DeGraff, David J., Tang, Moon-shong, Zhang, Yingkai, Wu, Xue-Ru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8024281/
https://www.ncbi.nlm.nih.gov/pubmed/33824349
http://dx.doi.org/10.1038/s41467-021-22327-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8024281/
https://www.ncbi.nlm.nih.gov/pubmed/33824349
http://dx.doi.org/10.1038/s41467-021-22327-5

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