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Dominant role of CDKN2B/p15INK4B of 9p21.3 tumor suppressor hub in inhibition of cell-cycle and glycolysis

Human chromosome 9p21.3 is susceptible to inactivation in cell immortalization and diseases, such as cancer, coronary artery disease and type-2 diabetes. Although this locus encodes three cyclin-dependent kinase (CDK) inhibitors (p15(INK4B), p14(ARF) and p16(INK4A)), our understanding of their funct...

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Detalles Bibliográficos
Autores principales:	Xia, Yong, Liu, Yan, Yang, Chao, Simeone, Diane M., Sun, Tung-Tien, DeGraff, David J., Tang, Moon-shong, Zhang, Yingkai, Wu, Xue-Ru
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8024281/ https://www.ncbi.nlm.nih.gov/pubmed/33824349 http://dx.doi.org/10.1038/s41467-021-22327-5

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