Cargando…
Dominant role of CDKN2B/p15INK4B of 9p21.3 tumor suppressor hub in inhibition of cell-cycle and glycolysis
Human chromosome 9p21.3 is susceptible to inactivation in cell immortalization and diseases, such as cancer, coronary artery disease and type-2 diabetes. Although this locus encodes three cyclin-dependent kinase (CDK) inhibitors (p15(INK4B), p14(ARF) and p16(INK4A)), our understanding of their funct...
Autores principales: | Xia, Yong, Liu, Yan, Yang, Chao, Simeone, Diane M., Sun, Tung-Tien, DeGraff, David J., Tang, Moon-shong, Zhang, Yingkai, Wu, Xue-Ru |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8024281/ https://www.ncbi.nlm.nih.gov/pubmed/33824349 http://dx.doi.org/10.1038/s41467-021-22327-5 |
Ejemplares similares
-
Effect of 9p21.3 (lncRNA and CDKN2A/2B) variant on lipid profile
por: Wei, Baozhu, et al.
Publicado: (2022) -
A variant at 9p21.3 functionally implicates CDKN2B in paediatric B-cell precursor acute lymphoblastic leukaemia aetiology
por: Hungate, Eric A., et al.
Publicado: (2016) -
A Functional Variant on 9p21.3 Related to Glioma Risk Affects Enhancer Activity and Modulates Expression of CDKN2B‐AS1
por: Ali, Mourad Wagdy, et al.
Publicado: (2021) -
9p21.3 Microdeletion involving CDKN2A/2B in a young patient with multiple primary cancers and review of the literature
por: Jensen, Marlene Richter, et al.
Publicado: (2022) -
Loss of heterozygosity of CDKN2A (p16INK4a) and RB1 tumor suppressor genes in testicular germ cell tumors
por: Vladusic, Tomislav, et al.
Publicado: (2010)